info:eu-repo/semantics/article
Fasciola hepatica products induce apoptosis of peritoneal macrophages
Fecha
2012-08Registro en:
Guasconi, Lorena; Serradell, Marianela del Carmen.; Masih, Diana Teresa; Fasciola hepatica products induce apoptosis of peritoneal macrophages; Elsevier Science; Veterinary Immunology And Immunopathology; 148; 3-4; 8-2012; 359-363
0165-2427
CONICET Digital
CONICET
Autor
Guasconi, Lorena
Serradell, Marianela del Carmen.
Masih, Diana Teresa
Resumen
Immunomodulatory properties have been described for Fasciola hepatica excretory-secretory products (FhESP), with their interaction with the innate immune cells being crucial during the early stages of infection. Previously, we demonstrated that FhESP induce eosinophil apoptosis. In this work, the ability of FhESP to induce apoptosis of peritoneal macrophages was evaluated.These parasite products were observed to induce apoptosis in peritoneal macrophages stimulated in vitro with FhESP, as well as in cells recovered from infected mice. The ability of FhESP to modify the viability of macrophages by apoptosis induction may constitute a crucial event for extending its survival in the host. © 2012 Elsevier B.V.