Artículos de revistas
Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
Fecha
2014-01Registro en:
Garro, Hugo Alejandro; Manzur, Maria Jimena; Ciuffo, Gladys Maria; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework; Elsevier; Bioorganic & Medicinal Chemistry Letters; 24; 3; 1-2014; 760-764
0960-894X
Autor
Garro, Hugo Alejandro
Manzur, Maria Jimena
Ciuffo, Gladys Maria
Tonn, Carlos Eugenio
Pungitore, Carlos Rodolfo
Resumen
Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 lM, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 lM, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs.