Artículos de revistas
Hypothermia prevents the development of ischemic proliferative retinopathy induced by severe perinatal asphyxia
Fecha
2010-01Registro en:
Rey Funes, Manuel; Ibarra, Mariano Esteban; Dorfman, Verónica Berta; López, Ester María; Lopez, Juan Jose; et al.; Hypothermia prevents the development of ischemic proliferative retinopathy induced by severe perinatal asphyxia; Elsevier; Experimental Eye Research; 90; 1; 1-2010; 113-120
0014-4835
1096-0007
Autor
Rey Funes, Manuel
Ibarra, Mariano Esteban
Dorfman, Verónica Berta
López, Ester María
Lopez, Juan Jose
Coirini, Hector
Loidl, Cesar Fabian
Resumen
Obstetric complications, such as perinatal asphyxia, may cause retinal injuries as retinopathy of prematurity (ROP), a type of ischemic proliferative retinopathy. Up to date there are no appropriate experimental models for studying the long-term sequels of this disease. In the present work, we present an experimental model of perinatal asphyxia which shows structural and ultrastructural retinal alterations at the most inner layers of the retina, such as neurodegeneration, development of neoformed vessels and glial reaction, which are compatible with the histopathological description of ROP. Besides, the application of hypothermia during perinatal asphyxia showed effective results preventing cellular and morphological alterations. This study may contribute to the development of therapies in order to either ameliorate or prevent retinal damage. In this manner, hypothermia may improve life quality and decrease medical, family and social costs of these avoidable causes of blindness.