Artículos de revistas
Chemical structure and anticoagulant activity of highly pyruvylated sulfated galactans from tropical green seaweeds of the order Bryopsidales
Fecha
2015-05Registro en:
Arata, Paula Ximena; Quintana, Irene Luisa; Canelon Gonzalez, Dilsia Josefina; Vera, Beatriz E.; Compagnone, Reinaldo S.; et al.; Chemical structure and anticoagulant activity of highly pyruvylated sulfated galactans from tropical green seaweeds of the order Bryopsidales; Elsevier; Carbohydrate Polymers; 122; 5-2015; 376-386
0144-8617
Autor
Arata, Paula Ximena
Quintana, Irene Luisa
Canelon Gonzalez, Dilsia Josefina
Vera, Beatriz E.
Compagnone, Reinaldo S.
Ciancia, Marina
Resumen
Sulfated and pyruvylated galactans were isolated from three tropical species of the Bryopsidales, Penicillus capitatus, Udotea flabellum, and Halimeda opuntia. They represent the only important sulfated polysaccharides present in the cell walls of these highly calcified seaweeds of the suborder Halimedineae. Their structural features were studied by chemical analyses and NMR spectroscopy. Their backbone comprises 3-, 6-, and 3,6-linkages, constituted by major amounts of 3-linked 4,6-O-(1′-carboxy)ethylidene-d-galactopyranose units in part sulfated on C-2. Sulfation on C-2 was not found in galactans from other seaweeds of this order. In addition, a complex sulfation pattern, comprising also 4-, 6-, and 4,6-disulfated galactose units was found. A fraction from P. capitatus, F1, showed a moderate anticoagulant activity, evaluated by general coagulation tests and also kinetics of fibrin formation was assayed. Besides, preliminary results suggest that one of the possible mechanisms involved is direct thrombin inhibition.