Artículos de revistas
In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides
Fecha
2013-10Registro en:
Perez Recalde, Maria Mercedes; Matulewicz, Maria Cristina; Pujol, Carlos Alberto; Carlucci, Maria Josefina; In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides; Elsevier Science; International Journal Of Biological Macromolecules; 63; 10-2013; 38-42
0141-8130
Autor
Perez Recalde, Maria Mercedes
Matulewicz, Maria Cristina
Pujol, Carlos Alberto
Carlucci, Maria Josefina
Resumen
Water-soluble sulfated polysaccharides from the red seaweed Nemalion helminthoides: two xylomannan fractions (N3 and N4) and a mannan fraction (N6), were investigated to determine their in vitro and in vivo immunomodulatory activities. N3 and N4 induced in vitro proliferation of macrophages of the murine cell line RAW 264.7 and significantly stimulated the production of nitric oxide (NO) and cytokines (IL-6 and TNF-a) in the same cells, whereas this response was not observed with the mannan N6. The cytokine production was also stimulated by sulfated xylomannans in vivo in BALB/c mice inoculated intravenously with these polysaccharides. Remarkably, when mice were treated with N3 and N4 one hour before being infected with Herpes simplex virus type 2, they remained asymptomatic with no signs of disease. The in vitro and in vivo results suggest that sulfated xylomannans could be strong immunomodulators.