info:eu-repo/semantics/article
Novel oxazine and oxazone dyes: aggregation behavior and physicochemical properties
Fecha
2016-11Registro en:
Urrutia, María Noel; Ortiz, Cristina Susana; Novel oxazine and oxazone dyes: aggregation behavior and physicochemical properties; Royal Society of Chemistry; New Journal of Chemistry; 40; 12; 11-2016; 10161-10171
1144-0546
CONICET Digital
CONICET
Autor
Urrutia, María Noel
Ortiz, Cristina Susana
Resumen
This research evaluated the synthesis and suitability of synthetic and commercial photosensitizers for use as potential photosensitizers in photodynamic therapy and photodynamic antimicrobial chemotherapy. Spectroscopic properties, experimental aggregation behavior in ethanol, N,N-dimethylformamide, water and water:polyethylene glycol 400, computational details, the ability to generate singlet oxygen, logPHPLC and theoretical logP were determined. All the compounds evaluated formed aggregates in different media. Novel brominated tested compounds exhibited higher lipophilicity and generation of singlet oxygen in comparison with the corresponding starting reagent. The studies showed that the tested oxazine and oxazone dyes satisfy the conditions of a potential drug in terms of physicochemical and photochemical properties.