Artículos de revistas
Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I
Fecha
2009-12Registro en:
Álvarez Colom, Olga; Neske, Adriana Neske; Chahboune, Nadia; Zafra Polo, M. Carmen; Bardon, Alicia del Valle; Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I; Wiley VCH Verlag; Chemistry and Biodiversity; 6; 3; 12-2009; 335-340
1612-1872
CONICET Digital
CONICET
Autor
Álvarez Colom, Olga
Neske, Adriana Neske
Chahboune, Nadia
Zafra Polo, M. Carmen
Bardon, Alicia del Valle
Resumen
Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuranpentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cisannonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.