Artículos de revistas
Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches
Fecha
2014-11Registro en:
Romanowski, Andrés; Garavaglia, Matías Javier; Goya, María Eugenia; Ghiringhelli, Pablo Daniel; Golombek, Diego Andres; Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches; Public Library of Science; Plos One; 9; 11; 11-2014; 1-16; e112871
1932-6203
1932-6203
CONICET Digital
CONICET
Autor
Romanowski, Andrés
Garavaglia, Matías Javier
Goya, María Eugenia
Ghiringhelli, Pablo Daniel
Golombek, Diego Andres
Resumen
Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa (Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana and Synechoccocus elongatus) in the proteomes of C. elegans and other members of the phylum Nematoda. With this approach we found that the Nematoda contain proteins most related to the core and accessory proteins of the insect and mammalian clocks, which provide new insights into the nematode clock and the evolution of the circadian system.