dc.creator | de Borba, Luana | |
dc.creator | Villordo, Sergio | |
dc.creator | Iglesias, Nestor Gabriel | |
dc.creator | Filomatori, Claudia Veronica | |
dc.creator | Gebhard, Leopoldo German | |
dc.creator | Gamarnik, Andrea Vanesa | |
dc.date.accessioned | 2017-07-05T19:44:32Z | |
dc.date.available | 2017-07-05T19:44:32Z | |
dc.date.created | 2017-07-05T19:44:32Z | |
dc.date.issued | 2015-03 | |
dc.identifier | de Borba, Luana; Villordo, Sergio; Iglesias, Nestor Gabriel; Filomatori, Claudia Veronica; Gebhard, Leopoldo German; et al.; Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication; American Society For Microbiology; Journal Of Virology; 89; 6; 3-2015; 3430-3437 | |
dc.identifier | 0022-538X | |
dc.identifier | http://hdl.handle.net/11336/19659 | |
dc.identifier | 1098-5514 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.description.abstract | The dengue virus genome is a dynamic molecule that adopts different conformations in the infected cell. Here, using RNA folding predictions, chemical probing analysis, RNA binding assays, and functional studies, we identified new cis-acting elements present in the capsid coding sequence that facilitate cyclization of the viral RNA by hybridization with a sequence involved in a local dumbbell structure at the viral 3' untranslated region (UTR). The identified interaction differentially enhances viral replication in mosquito and mammalian cells. | |
dc.language | eng | |
dc.publisher | American Society For Microbiology | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://jvi.asm.org/content/89/6/3430 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/JVI.02677-14 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Dengue | |
dc.subject | Flavivirus | |
dc.subject | Rna-Rna Interaction | |
dc.subject | Replication | |
dc.title | Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |