Artículos de revistas
In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome
Fecha
2017-06Registro en:
Di Pietro, Mariana; Pascuali, Natalia Marisa; Scotti, Leopoldina; Irusta, Griselda; Bas, Diana Ester; et al.; In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome; Oxford University Press; Molecular Human Reproduction; 23; 6; 6-2017; 417-427
1360-9947
1460-2407
CONICET Digital
CONICET
Autor
Di Pietro, Mariana
Pascuali, Natalia Marisa
Scotti, Leopoldina
Irusta, Griselda
Bas, Diana Ester
May, Maria
Tesone, Marta
Abramovich, Dalhia Nurit
Parborell, Maria Fernanda Agustina
Resumen
Can the bioactive lipid sphingosine-1 phosphate (S1P) act as an endothelial barrier-enhancing molecule and, in turn, restore the vascular integrity and homeostasis in a rat model of ovarian hyperstimulation syndrome (OHSS). In vivo administration of S1P may prevent the early onset of OHSS and decrease its severity. Although advances in the prediction and treatment of OHSS have been made, complete prevention has not been possible yet. S1P in follicular fluid from women at risk of developing OHSS are lower in comparison from women who are not at such risk and administration of S1P in an OHSS rat model decreases ovarian capillary permeability.