info:eu-repo/semantics/article
Differential effect of heterocyclic D-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression
Fecha
2014-08Registro en:
Gueron, Geraldine; Avanzo, Romina Edith; Schuster, Federico; Carabelos, María Noelia; Vazquez, Elba Susana; et al.; Differential effect of heterocyclic D-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression; Elsevier Masson; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie.; 68; 7; 8-2014; 847-854
0753-3322
Autor
Gueron, Geraldine
Avanzo, Romina Edith
Schuster, Federico
Carabelos, María Noelia
Vazquez, Elba Susana
Fascio, Mirta Liliana
D'accorso, Norma Beatriz
Resumen
New D-ribofuranoside derivatives containing two five membered heterocycles, isoxazole and triazole or two triazole rings, were synthesized. The final products as well as the synthetic precursors were physically and spectroscopically characterized. These new diheterocyclic derivatives together with other D-riboside compounds were assessed for their impact on PC3 cell line viability. We found that exposure of prostate cancer cells to some of these compounds caused a significant inhibition of cell growth and a G0/G1 cell cycle arrest, which was concomitant with alterations in the expression of proteins involved in cell cycle progression. Furthermore, the inhibitory activity was improved in di-heterocycles when the carbohydrate moiety was protected with a cyclopentylidene group compared to the isopropylidene analogues.