info:eu-repo/semantics/article
Antiradical activity of gallic acid included in lipid interphases
Fecha
2014-04Registro en:
Salcedo, Cecilia Luciana; Frías, María de los Ángeles; Cutró, Andrea Carmen; Nazareno, Mónica Azucena; Disalvo, Edgardo Anibal; Antiradical activity of gallic acid included in lipid interphases; Elsevier; Biochimica et Biophysica Acta - Biomembranes; 1838; 10; 4-2014; 2656-2661
0005-2736
CONICET Digital
CONICET
Autor
Salcedo, Cecilia Luciana
Frías, María de los Ángeles
Cutró, Andrea Carmen
Nazareno, Mónica Azucena
Disalvo, Edgardo Anibal
Resumen
Polyphenols are well known as antioxidant agents and by their effects on the hydration layers of lipid interphases. Among them, gallic acid and its derivatives are able to decrease the dipole potential and to act in water as a strong antioxidant. In this work we have studied both effects on lipid interphases in monolayers and bilayers of dimyristoylphosphatidylcholine. The results show that gallic acid (GA) increases the negative surface charges of large unilamellar vesicles (LUVs) and decreases the dipole potential of the lipid interphase. As a result, positively charged radical species such as ABTS+ are able to penetrate the membrane forming an association with GA. These results allow discussing the antiradical activity (ARA) of GA at the membrane phase which may be taking place in water spaces between the lipids.