Influence of overlapping genes on the evolution of hepatitis B virus

dc.creatorTorres, Carolina
dc.creatorBlanco Fernandez, Maria Dolores
dc.creatorFlichman, Diego Martin
dc.creatorCampos, Rodolfo Hector
dc.creatorMbayed, Viviana Andrea
dc.date.accessioned2015-09-03T18:31:47Z
dc.date.accessioned2018-11-06T11:29:58Z
dc.date.available2015-09-03T18:31:47Z
dc.date.available2018-11-06T11:29:58Z
dc.date.created2015-09-03T18:31:47Z
dc.date.issued2013-06-20
dc.identifierTorres, Carolina; Blanco Fernandez, Maria Dolores; Flichman, Diego Martin; Campos, Rodolfo Hector; Mbayed, Viviana Andrea; Influence of overlapping genes on the evolution of hepatitis B virus; Elsevier; Virology; 441; 1; 20-6-2013; 40-48
dc.identifier0042-6822
dc.identifierhttp://hdl.handle.net/11336/1930
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1853531
dc.description.abstractThe aim of this work was to analyse the influence of overlapping genes on the evolution of hepatitis B virus (HBV). A differential evolutionary behaviour among genetic regions and clinical status was found. Dissimilar levels of conservation of the different protein regions could derive from alternative mechanisms to maintain functionality. We propose that, in overlapping regions, selective constraints on one of the genes could drive the substitution process. This would allow protein conservation in one gene by synonymous substitutions while mechanisms of tolerance to the change operate in the overlapping gene (e.g. usage of amino acids with high-degeneracy codons, differential codon usage and replacement by physicochemically similar amino acids). In addition, differential selection pressure according to the HBeAg status was found in all genes, suggesting that the immune response could be one of the factors that would constrain viral replication by interacting with different HBV proteins during the HBeAg(-) stage
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1016/j.virol.2013.02.027
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0042682213001426
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHepatitis B Virus
dc.subjectEvolution
dc.subjectOverlapping genes
dc.subjectSelective pressures
dc.titleInfluence of overlapping genes on the evolution of hepatitis B virus
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución