info:eu-repo/semantics/article
Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
Fecha
2013-04Registro en:
Pasqualone, Magalí; Oberti, Tamara Gisela; Andreetta, Héctor Alfredo; Cortizo, Maria Susana; Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties; Springer; Journal of Materials Science: Materials In Medicine; 24; 7; 4-2013; 1683-1692
0957-4530
Autor
Pasqualone, Magalí
Oberti, Tamara Gisela
Andreetta, Héctor Alfredo
Cortizo, Maria Susana
Resumen
Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.