Artículos de revistas
Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A Motif in electron cycling
Fecha
2014-06Registro en:
Dikshit, Kanak L.; Luque, F. Javier; Estrin, Dario Ariel; Parkesh, R.; Datta, H.; Marti, Marcelo Adrian; et al.; Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A Motif in electron cycling
; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 289; 6-2014; 21573-21583
0021-9258
CONICET Digital
CONICET
Autor
Singh, Sandeep
Thakur, Naveen
Oliveira, Ana
Petruk, Ariel Alcides
Hade, Mangesh Dattu
Sethi, Deepti
Bidon Chanal, Axel
Marti, Marcelo Adrian
Datta, H.
Parkesh, R.
Estrin, Dario Ariel
Luque, F. Javier
Dikshit, Kanak L.
Resumen
Background: The HbN of Mycobacterium tuberculosis carries a potent nitric-oxide dioxygenase activity despite lacking a reductase domain. Results: The NADH-ferredoxin reductase system acts as an efficient partner for the reduction of HbN. Conclusion: The interactions of HbN with the reductase are modulated by its CD loop and the Pre-A region. Significance: The present study provides new insights into the mechanism of electron transfer during nitric oxide detoxification by HbN.