Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety

Barradas, Jose Sebastian; Errea, María Inés; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz; D'accorso, Norma Beatriz

Artículos de revistas

Fecha

2013-10

Registro en:

Damonte, Elsa Beatriz; Sepúlveda, Claudia Soledad; Errea, María Inés; Barradas, Jose Sebastian; D'accorso, Norma Beatriz; Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety; Wiley; Journal Of Heterocyclic Chemistry; 51; 1; 10-2013; 96-100

0022-152X

http://hdl.handle.net/11336/30961

CONICET Digital

CONICET

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1850626

Autor

Barradas, Jose Sebastian

Errea, María Inés

Sepúlveda, Claudia Soledad

Damonte, Elsa Beatriz

D'accorso, Norma Beatriz

Institución

Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina)

Resumen

Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated.

Materias

PYRRILO[2,1-b]THIAZOLES

MICROWAVE ASSISTED

CARBOHYDRATES

ANTIVIRAL ACTIVITY

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