info:eu-repo/semantics/article
A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study
Registro en:
Gimeno, Marina; Pinczowski, Pedro; Pérez, Marta; Giorello, Antonella; Martinez, Miguel Angel; et al.; A controlled antibiotic release system to prevent orthopedic-implant associated infections: An in vitro study; Elsevier; European Journal Of Pharmaceutics And Biopharmaceutics; 96; 10-2015; 264-271
0939-6411
CONICET Digital
CONICET
Autor
Gimeno, Marina
Pinczowski, Pedro
Pérez, Marta
Giorello, Antonella
Martinez, Miguel Angel
Santamaría, Jesús
Arruebo, Manuel
Luján, Lluis
Resumen
A new device for local delivery of antibiotics is presented, with potential use as a drug-eluting fixation pin for orthopedic applications. The implant consists of a stainless steel hollow tubular reservoir packed with the desired antibiotic. Release takes place through several orifices previously drilled in the reservoir wall, a process that does not compromise the mechanical properties required for the implant. Depending on the antibiotic chosen and the number of orifices, the release profile can be tailored from a rapid release of the load (ca. 20 h) to a combination of rapid initial release and slower, sustained release for a longer period of time (ca. 200 h). An excellent bactericidal action is obtained, with 4-log reductions achieved in as little as 2 h, and total bacterial eradication in 8 h using 6-pinholed implants filled with cefazolin. Fil: Gimeno, Marina. Universidad de Zaragoza; España Fil: Pinczowski, Pedro. Universidad de Zaragoza; España Fil: Pérez, Marta. Universidad de Zaragoza; España Fil: Giorello, Antonella. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica ; Argentina Fil: Martinez, Miguel Angel. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España Fil: Santamaría, Jesús. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España Fil: Arruebo, Manuel. Universidad de Zaragoza; España. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN; España Fil: Luján, Lluis. Universidad de Zaragoza; España