info:eu-repo/semantics/article
Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains
Registro en:
Baez, Alejandra Lidia; Lo Presti, Maria Silvina; Fretes, Ricardo; Diaz, Cintia; Pons, Patricia; et al.; Chronic indeterminate phase of Chagas’ disease: mitochondrial involvement in infection with two strains; Cambridge University Press; Parasitology; 140; 3; 3-2013; 414-421
0031-1820
1469-8161
Autor
Baez, Alejandra Lidia
Lo Presti, Maria Silvina
Fretes, Ricardo
Diaz, Cintia
Pons, Patricia
Bazán, Paola Carolina
Strauss, Mariana
Rivarola, Héctor Walter
Paglini Oliva, Patricia
Resumen
Chagasic cardiopathy has become one of the most frequent causes of heart failure and sudden death, as well as one of the most common causes of cardio-embolic stroke in Latin America. The myocyte response to oxidative stress involves the progression of cellular changes, primarily targeting the mitochondria and modifying therefore the energy supply. In this paper we analysed the effect of the infection of mice with 2 different strains of Trypanosoma cruzi (Tulahuen and SGO Z12) in the chronic indeterminate stage (75 days post-infection), upon the structure and function of cardiac mitochondria. The structural results showed that 83% of the mitochondria from the Tulahuen-infected mice presented an increase in their matrix and 91% of the mitochondria from the SGO Z12-infected group showed a reduction in their diameter (P< 0·05). When the Krebs cycle and mitochondrial respiratory chain functionality was analysed through the measurement of the citrate synthase and complexes I to IV activity, it showed that their activity was altered in all cases in a similar manner in both infected groups. In this paper we have demonstrated that the chronic indeterminate phase is not ‘silent’ and that cardiac mitochondria are clearly involved in the genesis and progression to the chronic chagasic cardiopathy when different factors alter the host-parasite equilibrium. Fil: Baez, Alejandra Lidia. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina Fil: Fretes, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; Argentina Fil: Diaz, Cintia. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; Argentina Fil: Pons, Patricia. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina Fil: Bazán, Paola Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina Fil: Rivarola, Héctor Walter. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina Fil: Paglini Oliva, Patricia. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisica Biomedica; Argentina