info:eu-repo/semantics/article
Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
Registro en:
Bigliani, María Celeste; Rosso, María Celeste; Zunino, María Paula; Baiardi, Gustavo Carlos; Ponce, Andrés Alberto; Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study; Taylor & Francis; Natural Product Research; 27; 18; 1-2013; 1682-1685
1478-6419
1478-6427
Autor
Bigliani, María Celeste
Rosso, María Celeste
Zunino, María Paula
Baiardi, Gustavo Carlos
Ponce, Andrés Alberto
Resumen
The purpose of this study was to examine the effect of orally administered Uncaria tomentosa aqueous extracts (UTE) (Willd. ex Roem. & Schult.) DC. (Rubiaceae) during 7, 15, 30 and 90 days of treatment on the expression of anxiety, as expressed in the elevated plus maze test in male Albino Swiss mice. UTE revealed an anxiogenic effect in relation to the control group at 15 and 30 days, but it was reversed after 90 days of administration, without affecting the locomotor activity or any deleterious effects on the overall performance of the animal, either for its ambulation, or clinical status, and body weight and organ weight/body weight from liver, lung and kidney were unaffected. These biphasic effects are usually indicative of heterogeneity in sites of action due to the presence of many alkaloids (speciophylline, uncarine F and uncarine E) and flavanols (catechin and epigallocatechin) identified and isolated from UTE. Fil: Bigliani, María Celeste. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisiologia Humana; Argentina Fil: Rosso, María Celeste. Universidad Nacional de la Rioja; Argentina Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina Fil: Baiardi, Gustavo Carlos. Universidad Catolica de Cordoba. Facultad de Cs.quimicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ponce, Andrés Alberto. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisiologia Humana; Argentina. Universidad Nacional de la Rioja; Argentina