Effect of β-adrenoceptors on the behaviour induced by the neuropeptide glutamic acid isoleucine amide

dc.creatorSánchez Borzone, Mariela E.
dc.creatorAttademo, Andres Maximiliano
dc.creatorBaiardi, Gustavo Carlos
dc.creatorCelis, María Ester
dc.date2007-07
dc.identifierhttp://hdl.handle.net/11336/59030
dc.identifierSánchez Borzone, Mariela E.; Attademo, Andres Maximiliano; Baiardi, Gustavo Carlos; Celis, María Ester; Effect of β-adrenoceptors on the behaviour induced by the neuropeptide glutamic acid isoleucine amide; Elsevier Science; European Journal of Pharmacology; 568; 1-3; 7-2007; 186-191
dc.identifier0014-2999
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionExcessive grooming behaviour is induced by intracerebroventricular injections of the neuropeptide glutamic acid isoleucine amide (neuropeptide-EI), via the activation of A-10 dopaminergic neurons and the noradrenergic system. Our object was to study the latter system involved in these behaviours, using male Wistar rats weighing 250-300 g with i.c.v. implants. The results show that all the adrenoceptor antagonists "per se" do not affect excessive grooming behaviour or motor activity. Intracerebroventricular administration of propranolol, a general β-adrenoceptor antagonist, before neuropeptide-EI, inhibited the induced excessive grooming behaviour in a dose dependent manner. Metoprolol, a β1-adrenoceptor antagonist, also blocked this behaviour. However, intracerebroventricular injections of phentolamine, an α-adrenoceptor antagonist, and ((±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol), a β2-adrenoceptor antagonist, had no effect on the behaviour induced by neuropeptide-EI induced behaviour for any of the doses tested. On the other hand, isoproterenol, a general β-adrenoceptor agonist and dobutamine, a β1-adrenoceptor agonist, both elicited similar behaviours as those induced by neuropeptide-EI. These results support the hypothesis that a relationship exists between neuropeptide-EI and β-adrenoceptors, more specifically the β1-adrenoceptor, as found with other similar endogenous peptides such as neurotensin, cholecystin, substance P and α-melanocyte stimulating hormone. Hence, neuropeptide-EI could probably be exerting a neuromodulating effect on the central nervous system. © 2007 Elsevier B.V. All rights reserved.
dc.descriptionFil: Sánchez Borzone, Mariela E.. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bacteriología y Virología Médica. Laboratorio de Ciencias Fisiológicas; Argentina
dc.descriptionFil: Attademo, Andres Maximiliano. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bacteriología y Virología Médica. Laboratorio de Ciencias Fisiológicas; Argentina. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias. Laboratorio de Ecotoxicologia; Argentina
dc.descriptionFil: Baiardi, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bacteriología y Virología Médica. Laboratorio de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.descriptionFil: Celis, María Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bacteriología y Virología Médica. Laboratorio de Ciencias Fisiológicas; Argentina
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dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014299907004797
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejphar.2007.04.024
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectExcessive Grooming Behaviour
dc.subjectI.C.V. Injection
dc.subjectNeuropeptide Ei
dc.subjectNoradrenergic System
dc.subjecthttps://purl.org/becyt/ford/3.3
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleEffect of β-adrenoceptors on the behaviour induced by the neuropeptide glutamic acid isoleucine amide
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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