info:eu-repo/semantics/article
Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil
Registro en:
Vianna, Fernanda Sales Luiz; Oliveira, Marcelo Zagonel de; Sanseverino, Maria Teresa Vieira; Morelo, Elaine Faria; Rabello Neto, Dacio de Lyra; et al.; Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 53; 6-2015; 63-67
0890-6238
CONICET Digital
CONICET
Autor
Vianna, Fernanda Sales Luiz
Oliveira, Marcelo Zagonel de
Sanseverino, Maria Teresa Vieira
Morelo, Elaine Faria
Rabello Neto, Dacio de Lyra
López Camelo, Jorge Santiago
Camey, Suzi Alves
Schuler Faccini, Lavinia
Resumen
Introduction: Thalidomide causes congenital defects in children, such as limb reduction defects. Currently, it is used for a few indications; in Brazil, where leprosy is endemic, thalidomide is used for the treatment of erythema nodosum leprosum, and recent cases of thalidomide embryopathy have been reported. Methods: We analyzed the frequency of births with phenotypes consistent with thalidomide embryopathy (TEP) and correlated this with the distribution of thalidomide and the prevalence of leprosy between 2005 and 2010 in Brazil. Results: A total of 5,889,210 thalidomide tablets were distributed; the prevalence of limb reduction defects was 1.60 (CI95%: 1.54–1.66) and TEP was 0.11 (CI95%: 0.10–0.13) per 10,000 births. Poisson regression showed an increase in cases of TEP and limb reduction defects per 100,000 tablets dispensed. Clusters and geographical isolates were identified in several regions. Conclusions: There is a correlation between thalidomide and TEP showing that thalidomide embryopathy should be monitored in countries where this medication is available. Fil: Vianna, Fernanda Sales Luiz. Instituto Nacional de Genética Médica Populacional; Brasil. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; Brasil Fil: Oliveira, Marcelo Zagonel de. Instituto Nacional de Genética Médica Populacional; Brasil. Universidade Federal do Rio Grande do Sul; Brasil Fil: Sanseverino, Maria Teresa Vieira. Instituto Nacional de Genética Médica Populacional; Brasil. Hospital de Clínicas de Porto Alegre; Brasil Fil: Morelo, Elaine Faria. Programa Nacional da Hanseníase; Brasil Fil: Rabello Neto, Dacio de Lyra. Ministério da Saúde do Brasilia; Brasil Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina Fil: Camey, Suzi Alves. Universidade Federal do Rio Grande do Sul; Brasil Fil: Schuler Faccini, Lavinia. Hospital de Clínicas de Porto Alegre; Brasil. Instituto Nacional de Genética Médica Populacional; Brasil. Universidade Federal do Rio Grande do Sul; Brasil