info:eu-repo/semantics/article
Molecular structure, bioavailability and bioactivity of [Cu(o-phen)2(cnge)](NO3)2 · 2H2O and [Cu(o-phen)(cnge)(H2O)(NO3)2] complexes
Registro en:
Ferrer, Evelina Gloria; López Tévez, Libertad Leonor; Baeza, Natalia; Correa, María Jimena; Okulik, Nora Beatriz; et al.; Molecular structure, bioavailability and bioactivity of [Cu(o-phen)2(cnge)](NO3)2 · 2H2O and [Cu(o-phen)(cnge)(H2O)(NO3)2] complexes; Elsevier Science Inc; Journal of Inorganic Biochemistry; 101; 5; 5-2007; 741-749
0162-0134
CONICET Digital
CONICET
Autor
Ferrer, Evelina Gloria
López Tévez, Libertad Leonor
Baeza, Natalia
Correa, María Jimena
Okulik, Nora Beatriz
Lezama, Luis
Rojo, Teófilo
Castellano, Eduardo E.
Piro, Oscar Enrique
Williams, Patricia Ana María
Resumen
Two Cu(II) complexes with cyanoguanidine (cnge) and o-phenanthroline, [Cu(o-phen)2(cnge)](NO3)2 · 2H2O (1) and [Cu(o-phen)(cnge)(H2O)(NO3)2] (2), have been synthesized using different experimental techniques and characterized by elemental analyses, FTIR, diffuse and UV-vis spectra and EPR and magnetic moment measurements techniques. The crystal structures of both complexes were solved by X-ray diffraction methods. Complex (1) crystallizes in the monoclinic space group C2/c with a = 12.621(5), b = 31.968(3), c = 15.39(1) Å, β = 111.68(4)°, and Z = 8 and complex (2) in the monoclinic space group P21/n with a = 10.245(1), b = 13.923(2), c = 12.391(2) Å, β = 98.07(1)°, and Z = 4. The environments of the copper(II) center are trigonal bipyramidal (TBP) for [Cu(o-phen)2(cnge)]2+ and an elongated octahedron for [Cu(o-phen)(cnge)(H2O)(NO3)2]. Solution studies have been performed to determine the species distribution. The superoxide dismutase (SOD) activities of both complexes have also been tested in order to determine if these compounds mimic the enzymatic action of the enzyme SOD that protects cells against peroxide radicals. © 2007 Elsevier Inc. All rights reserved. Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina Fil: López Tévez, Libertad Leonor. Universidad Nacional del Nordeste; Argentina Fil: Baeza, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina Fil: Correa, María Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina Fil: Okulik, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Chaco Austral. Departamento de Ciencias Básicas y Aplicadas. Laboratorio de Ingeniería de las Reacciones Químicas; Argentina Fil: Lezama, Luis. Universidad del Pais Vasco - Euskal Herriko Unibertsitatea, Campus Bizkaia; Fil: Rojo, Teófilo. Universidad del Pais Vasco - Euskal Herriko Unibertsitatea, Campus Bizkaia; Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina Fil: Williams, Patricia Ana María. Universidad Nacional de La Plata. Facultad de Ciencias Exactas; Argentina