Artículos de revistas
Homocysteine, folate, hs-C-reactive protein, tumor necrosis factor alpha and inflammatory proteins: are these biomarkers related to nutritional status and cardiovascular risk in childhood-onset systemic lupus erythematosus?
Fecha
2018Registro en:
Pediatric Rheumatology. 2018 Jan 09;16(1):4
10.1186/s12969-017-0220-y
Autor
Salomão, Roberta Garcia
Carvalho, Luciana Martins de
Izumi, Clarice
Czernisz, Érika Silva
Rosa, Jose Cesar
Antonini, Sonir Roberto Rauber
Bueno, Ana Carolina
Almada, Maria Olimpia Ribeiro do Vale
Coelho-Landell, Carolina de Almeida
Jordão, Alceu Afonso
Ferriani, Virginia Paes Leme
Monteiro, Jacqueline Pontes
Institución
Resumen
Abstract
Background
Childhood-onset systemic lupus erythematosus (c-SLE) is a chronic autoimmune disease which increases cardiovascular risk factors (CRF) such as elevated homocysteine, TNF-α, and hs-C reactive protein.
Methods
We evaluated BMI, waist circumference (WC), 24-h recalls, SLEDAI-2 K, SLICC/ACR-DI, serum levels of homocysteine, folate, TNF-α, hs-C reactive protein, lipid profile, proteomic data, and duration of corticosteroid therapy in 19 c-SLE and 38 healthy volunteers. Physiological and anthropometric variables of c-SLE and healthy controls were compared by ANCOVA. k-cluster was used to separate c-SLE into two different groups with the best and the worst metabolic profile according to previous analysis showing some metabolites that were statistically different from controls, such as homocysteine, TNF-α, hs-CRP and folate levels. These two clusters were again compared with the control group regarding nutritional parameters, lipid profile and also proteomic data.
Results
Individuals with c-SLE presented higher BMI, WC, homocysteine, triglycerides, TNF-α, hs-CRP and lower folate levels when compared to controls. We found 10 proteins whose relative abundances were statistically different between control group and lupus clusters with the best (LCBMP) and the worst metabolic profile (LCWMP). A significant positive correlation was found between TNF-α and triglycerides and between hs-CRP and duration of corticosteroid therapy.
Conclusion
Cardiovascular disease (CVD) risk parameters were worse in c-SLE. A less protective CVD proteomic profile was found in LCWMP.