dc.creatorArruda, Guilherme Ferraz de
dc.creatorCosta, Luciano da Fontoura
dc.creatorSchubert, Dirk
dc.creatorRodrigues, Francisco Aparecido
dc.date.accessioned2016-06-22T19:07:25Z
dc.date.accessioned2018-07-04T17:09:39Z
dc.date.available2016-06-22T19:07:25Z
dc.date.available2018-07-04T17:09:39Z
dc.date.created2016-06-22T19:07:25Z
dc.date.issued2014-08
dc.identifierClinical Neurophysiology, Shannon : Elsevier, v. 125, n. 8, p. 1589-1595, Aug. 2014
dc.identifier1388-2457
dc.identifierhttp://www.producao.usp.br/handle/BDPI/50354
dc.identifier10.1016/j.clinph.2013.11.036
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1645472
dc.description.abstractObjective: Schizophrenia is a neuropsychiatric disorder characterized by cognitive and emotional deficits and associated with various abnormalities in the organization of neural circuits. It is currently unclear how and to which extend the global network organization is changed due to such disorder. In this work, we analyzed cortical networks of healthy subjects and patients with child-onset schizophrenia to address this issue. Methods: We performed a comparison of cortical networks extracted from functional MRI data of patients with schizophrenia and healthy subjects considering their topological and dynamical properties. Results: Among 54 network measures tested, only four contributed substantially to a discrimination between the classes of healthy and schizophrenic subjects, with a sensitivity of 90% and specificity of 74%. However, such classes of networks did not differ significantly with respect to the level of network resilience and synchronization. Conclusions: Schizophrenic subjects have cortical regions with higher variance of network centrality, but less modular structure. Significance: Our findings suggest that it is possible to establish data analysis routines that allow automatic diagnosis of a multifaceted disease like child-onset schizophrenia based on fMRI data of individual subjects and extracted network properties.
dc.languageeng
dc.publisherElsevier
dc.publisherShannon
dc.relationClinical Neurophysiology
dc.rightsCopyright International Federation of Clinical Neurophysiology
dc.rightsrestrictedAccess
dc.subjectCortical networks
dc.subjectSchizophrenia
dc.subjectChild-onset schizophrenia
dc.subjectComplex networks
dc.titleStructure and dynamics of functional networks in child-onset schizophrenia
dc.typeArtículos de revistas


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