Artículos de revistas
Myocardium tissue changes caused by electrical transthoracic discharges in rats
Fecha
2009-10-23Registro en:
International Archives of Medicine. 2009 Oct 23;2(1):31
Autor
Ferreira, Marcelo
Ferreira, Celso
Carlos de Abreu, Luiz
Valenti, Vitor E
Murad, Neif
Meneghini, Adriano
Filho, Celso F
Filho, Angelini d O J
Institución
Resumen
Abstract
Background
Cardiomyocytes cytoarchitecture changes caused by transthoracic countershocks have been focused recently. We aimed to evaluate the effects of electrical discharge application in the mitochondria structure in atrial myocardium of rats.
Methods
An electrical cardioverter was adapted to small rodent animals for our research. Electrical discharges were applied to the precordial region of 30 albino rats: (1) control group - animals that remained on resting period and were afterwards sacrificed; (2) electrical discharge group - animals that remained on resting period, followed by ten electrical discharges of 300 mV and sacrificed, and; (3) electrical post-discharge group - animals that remained on a resting period and received ten electrical discharges like the electrical discharge group, but were sacrificed seven days subsequently. We examined liver, adrenal and left atrium tissue fragments of the three groups.
Results
It was observed in control and post-discharge groups a normal cellular structure aspect with preserved architecture of cardiomyocytes and continuous sarcoplasmic membrane integrity. On the other hand, cardiac muscle fibers with mitochondrial edema and lysis occurred in the discharge group. Glycogen and adrenal lipids were not depleted in all groups.
Conclusion
These data suggest that transthoracic electrical discharges induce mitochondrial injuries in atrial cardiac cells of rats.