Actas de congresos
Potential applications of Desferrioxamine and other iron chelators for the clinical management of neurodegenerative diseases.
Fecha
2014-05-21Registro en:
1st Symposium on Current Topics in Molecular Biophysics, 2014, São Paulo
Autor
Suárez, Eduardo Díaz
Institución
Resumen
Recently, potential applications of Desferrioxamine and other
iron chelators have attracted attention for the clinicai management of
neurodegenerative diseases. Several studies in the literature indicate that
metal imbalance in the brain can be involved in neurodegenerative diseases
such as Parkinson and Alzheimer. Many genetic disorders in humans are
caused by imbalance of body iron. A strategy is to link the iron chelator to
peptides such as TAT or penetratin gain access to iron overloaded sites in the
brain. In this case, the study of the structure and binding modes of iron to the
chelator system helps to understand their biological mode of action.