Second-coordination-sphere effects increase the catalytic efficiency of an extended model for FeIIIMII purple acid phosphatases

Souza, Bernardo de; Kreft, Gabriel L.; Bortolotto, Tiago; Terenzi, Hernán; Bortoluzzi, Adailton J.; Castellano, Eduardo Ernesto; Peralta, Rosely A.; Domingos, Josiel B.; Neves, Ademir

Artículos de revistas

Fecha

2013-04

Registro en:

Inorganic Chemistry, Washington, DC : American Chemical Society - ACS, v. 52, n. 7, p. 3594-3596, Apr. 2013

0020-1669

http://www.producao.usp.br/handle/BDPI/45267

10.1021/ic400025j

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1640187

Autor

Souza, Bernardo de

Kreft, Gabriel L.

Bortolotto, Tiago

Terenzi, Hernán

Bortoluzzi, Adailton J.

Castellano, Eduardo Ernesto

Peralta, Rosely A.

Domingos, Josiel B.

Neves, Ademir

Institución

Universidade de São Paulo (Brasil)

Resumen

Herein we describe the synthesis of a new heterodinuclear FeIIICuII model complex for the active site of purple acid phosphatases and its binding to a polyamine chain, a model for the amino acid residues around the active site. The properties of these systems and their catalytic activity in the hydrolysis of bis(2,4-dinitrophenyl)phosphate are compared, and conclusions regarding the eﬀects of the second coordination sphere are drawn. The positive eﬀect of the polymeric chain on DNA hydrolysis is also described and discussed.

Materias

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