Artículos de revistas
Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: a still-puzzling diagnosis in autopsy
Date
2013Registration in:
Autopsy and Case Reports, v.3, n.4, p.29-36, 2013
10.4322/acr.2013.036
Author
Campos, Fernando Peixoto Ferraz de
Silva, Aloísio Souza Felipe da
Zerbini, Maria Claudia Nogueira
Martines, João Augusto dos Santos
Institutions
Abstract
Primary lung lymphoma is a rare entity accounting for approximately 0.3% of
all primary neoplasia of the lung and includes diffuse large B-cell lymphoma
(DLBL) and lymphomatoid granulomatosis (LYG). Considering that clinical
features may be similar, whereas epidemiology, morphology, and radiological
features are different, the authors report a case of a middle-aged man
who presented multiple pulmonary nodules in the lower lobes and groundglass
opacities scattered bilaterally on computed tomography. Clinically, he
presented a consumptive syndrome with respiratory failure and pleurisy,
which progressed until death. The autopsy findings were consistent with
lymphomatoid granulomatosis (LYG) grade 3/ diffuse large B-cell lymphoma
(DLBL). The authors call attention to the difficulty of establishing an accurate
diagnosis, mainly when the demonstration of EBV-infected atypical B-cells
fails.