Artículos de revistas
Early and late neurodegeneration and memory disruption after intracerebroventricular streptozotocin
Fecha
2012-10Registro en:
PHYSIOLOGY & BEHAVIOR, OXFORD, v. 107, n. 3, Part 1, pp. 401-413, OCT 10, 2012
0031-9384
10.1016/j.physbeh.2012.06.019
Autor
Santos, Taisa de Oliveira
Mazucanti, Caio Henrique Yokoyama
Xavier, Gilberto Fernando
Torrão, Andréa da Silva
Institución
Resumen
Glucose metabolism and insulin signaling disruptions in the brain have been proposed as a likely etiology of Alzheimer's disease. The aim of the present study was to investigate the time course of cognitive impairments induced by intracerebroventricular injection of streptozotocin (STZ) in rats and correlate them with the ensuing neurodegenerative process. Early and late effects of STZ were evaluated by using the reference and working memory versions of the Morris' water maze task and the evaluation of neurodegenerative markers by immunoblotting and the Fluoro-jade C histochemistry. The results revealed different types of behavioral and neurodegenerative responses, with distinct time courses. We observed an early disruption on the working memory as early as 3 h after STZ injections, which was followed by degenerative processes in the hippocampus at 1 and 15 days after STZ injections. Memory disruption increases over time and culminates with significant changes in amyloid-beta peptide and hyperphosphorylated Tau protein levels in distinct brain structures. These findings add information on the Alzheimer's disease-like STZ animal model and on the mechanisms underlying neurodegenerative processes. (C) 2012 Elsevier Inc. All rights reserved.