Artículos de revistas
Quercetin as a shuttle for labile iron
Fecha
2012Registro en:
JOURNAL OF INORGANIC BIOCHEMISTRY, NEW YORK, v. 107, n. 1, p. 34-39, FEB, 2012
0162-0134
10.1016/j.jinorgbio.2011.11.014
Autor
Baccan, Mayara Marinovic
Chiarelli Neto, Orlando
Pereira, Regina Mara Silva
Esposito, Breno Pannia
Institución
Resumen
The antioxidant activity of flavonoids may involve their ability to complex body iron in non-redox-active forms. In this study, it was found that the catechol flavonoids rutin and quercetin are able to suppress redox-active labile plasma iron (LPI) in both buffered solution and in iron-overloaded sera. Both flavonoids are effective in loading the metal into the iron-transport protein transferrin. Iron derivatives of quercetin and rutin are able to permeate cell membranes, however, only free quercetin is able to gain access to the cytosol and decrease intracellular labile iron pools. These results suggest that the antioxidant activity of quercetin may be dependent on its ability to shuttle labile iron from cell compartments followed by its transfer to transferrin. (C) 2011 Elsevier Inc. All rights reserved.