Artículos de revistas
An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling
Fecha
2012Registro en:
MATHEMATICAL AND COMPUTER MODELLING, OXFORD, v. 55, n. 41367, supl. 1, Part 3, pp. 342-366, FEB, 2012
0895-7177
10.1016/j.mcm.2011.08.008
Autor
Joly, Marcel
Pinto, Jose M.
Institución
Resumen
This work presents major results from a novel dynamic model intended to deterministically represent the complex relation between HIV-1 and the human immune system. The novel structure of the model extends previous work by representing different host anatomic compartments under a more in-depth cellular and molecular immunological phenomenology. Recently identified mechanisms related to HIV-1 infection as well as other well known relevant mechanisms typically ignored in mathematical models of HIV-1 pathogenesis and immunology, such as cell-cell transmission, are also addressed. (C) 2011 Elsevier Ltd. All rights reserved.