Artículos de revistas
The In Vitro and In Vivo Antitumour Activities of Nitrosyl Ruthenium Amine Complexes
Fecha
2012Registro en:
AUSTRALIAN JOURNAL OF CHEMISTRY, COLLINGWOOD, v. 65, n. 9, supl. 1, Part 3, pp. 1333-1341, FEB 20, 2012
0004-9425
10.1071/CH12245
Autor
Osti, Renata Zachi de
Serrano, Fabiana A.
Paschoalin, Thaysa
Massaoka, Mariana H. S.
Travassos, Luiz R.
Truzzi, Daniela Ramos
Rodrigues, Elaine G.
Franco, Douglas Wagner
Institución
Resumen
Ruthenium compounds of the type trans-[Ru(NO)(NH3)(4)(L)] X-3, L = N-heterocyclic ligands, P(OEt)(3), SO32-, X BF4- or PF6-, or [Ru(NO)Hedta], were tested for antitumour activity in vitro against murine melanoma and human tumour cells. The ruthenium complexes induced DNA fragmentation and morphological alterations suggestive of necrotic tumour cell death. The calculated IC50 values were lower than 100 mu M. Complexes for which L = isn or imN were partially effective in vivo in a syngeneic model of murine melanoma B16F10, increasing animal survival. In addition, the same ruthenium complexes effectively inhibited angiogenesis of HUVEC cells in vitro. The results suggest that these nitrosyl complexes are a promising platform to be explored for the development of novel antitumour agents.