Artículos de revistas
Clinical implication of 14-3-3 epsilon expression in gastric cancer
Fecha
2012Registro en:
WORLD JOURNAL OF GASTROENTEROLOGY, BEIJING, v. 18, n. 13, supl. 1, Part 1, pp. 1531-1537, APR 7, 2012
1007-9327
10.3748/wjg.v18.i13.1531
Autor
Leal, Mariana Ferreira
Calcagno, Danielle Queiroz
Demachki, Samia
Assumpcao, Paulo Pimentel
Chammas, Roger
Burbano, Rommel Rodriguez
Cardoso Smith, Marilia de Arruda
Institución
Resumen
AIM: To evaluate for the first time the protein and mRNA expression of 14-3-3 epsilon in gastric carcinogenesis. METHODS: 14-3-3 epsilon protein expression was determined by western blotting, and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples. RESULTS: Authors observed a significant reduction of 14-3-3 epsilon protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue, Reduced levels of 14-3-3 epsilon were also associated with diffuse-type GC and early-onset of this pathology. Our data suggest that reduced 14-3-3 epsilon may have a role in gastric carcinogenesis process. CONCLUSION: Our results reveal that the reduced 14-3-3 epsilon expression in GC and investigation of 14-3-3 epsilon interaction partners may help to elucidate the carcinogenesis process. (C) 2012 Baishideng. All rights reserved.