Artículos de revistas
Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in Sao Paulo, Brazil
Fecha
2012Registro en:
JOURNAL OF CLINICAL MICROBIOLOGY, WASHINGTON, v. 50, n. 6, supl. 4, Part 1, pp. 2122-2125, JUN, 2012
0095-1137
10.1128/JCM.00539-12
Autor
Mantovani, N. P.
Azevedo, R. G.
Rabelato, J. T.
Sanabani, S.
Diaz, R. S.
Komninakis, S. V.
Institución
Resumen
We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.