Artículos de revistas
The Differential Clinical Impact of Human Coronavirus Species in Children With Cystic Fibrosis
Fecha
2012Registro en:
JOURNAL OF INFECTIOUS DISEASES, CARY, v. 206, n. 3, supl. 1, Part 3, pp. 384-388, AUG 1, 2012
0022-1899
10.1093/infdis/jis274
Autor
Silva Filho, Luiz Vicente Ribeiro Ferreira da
Zerbinati, Rodrigo Melim
Tateno, Adriana Fumie
Boas, Lucy Santos Vilas
Almeida, Marina Buarque de
Levi, José Eduardo
Drexler, Jan Felix
Drosten, Christian
Pannuti, Claudio Sergio
Institución
Resumen
We investigated the clinical impact of human coronaviruses (HCoV) OC43, 229E, HKU1 and NL63 in pediatric patients with cystic fibrosis (CF) during routine and exacerbation visits. A total of 408 nasopharyngeal aspirate samples were obtained from 103 patients over a 1-year period. Samples positive for HCoV were submitted for nucleotide sequencing to determine the species. Nineteen samples (4.65%) were positive for HCoV, of which 8 were positive for NL63, 6 for OC43, 4 for HKU1, and 1 for 229E. Identification of HCoV was not associated with an increased rate of respiratory exacerbations, but NL63-positive patients had higher exacerbation rates than patients who were positive for other HCoV species.