Artículos de revistas
Peptides of the Constant Region of Antibodies Display Fungicidal Activity
Fecha
2012Registro en:
PLOS ONE, SAN FRANCISCO, v. 7, n. 3, supl. 1, Part 2, pp. 514-519, 44256, 2012
1932-6203
10.1371/journal.pone.0034105
Autor
Polonelli, Luciano
Ciociola, Tecla
Magliani, Walter
Zanello, Pier Paolo
D'Adda, Tiziana
Galati, Serena
De Bernardis, Flavia
Arancia, Silvia
Gabrielli, Elena
Pericolini, Eva
Vecchiarelli, Anna
Arruda, Denise C.
Pinto, Marcia R.
Travassos, Luiz R.
Pertinhez, Thelma A.
Spisni, Alberto
Conti, Stefania
Institución
Resumen
Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.