Artículos de revistas
Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
Fecha
2012Registro en:
INTERNATIONAL JOURNAL OF MORPHOLOGY, TEMUCO, v. 30, n. 1, supl. 1, Part 2, pp. 105-109, SEP-OCT, 2012
0717-9502
10.4067/S0717-95022012000100018
Autor
de Oliveira, David Moraes
Ferreira da Silveira, Marcia Maria
de Souza Andrade, Emanuel Savio
Veras Sobral, Ana Paula
Saquete Martins-Filho, Paulo Ricardo
Santos, Thiago de Santana
Amorim de Oliveira, Patricia Leimig
Peixoto, Aline Carvalho
Santana de Souza Santos, Jadson Alipio
Piva, Marta Rabello
Institución
Resumen
This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic epithelium. This study suggests that the odontogenic cells of the dental follicle might be proliferating during the rhizogenesis, while the squamous metaplasia and hyperplasia of the epithelial lining and proliferative odontogenic epithelial rests show the differentiation potential of dental follicles.