Artículos de revistas
TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma
Fecha
2013-08-02Registro en:
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, VALENCIA, v. 17, n. 1, supl. 1, Part 6, pp. E29-E34, JAN, 2012
1698-4447
10.4317/medoral.17344
Autor
Silva, Brunno Santos de Freitas
Yamamoto, Fernanda-Paula
Pontes, Flavia Sirotheau Corrêa
Cury, Sérgio Elias Vieira
Fonseca, Felipe-Paiva
Pontes, Helder Antonio Rebêlo
Júnior, Décio dos Santos Pinto
Institución
Resumen
Objectives: The aim of this study was to evaluate the immunoexpression of TWIST and p-Akt proteins in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC), correlating their expressions with the histological features of the lesions. Study design: Immunohistochemical studies were carried out on 10 normal oral epithelium, 30 OL and 20 OSCC formalin-fixed, paraffin-embedded tissue samples. Immunoperoxidase reactions for TWIST and p-Akt proteins were applied on the specimens and the positivity of the reactions was calculated for 1000 epithelial cells. Results: Kruskal-Wallis and Dunn's post tests revealed a significant difference in TWIST and p-Akt immunoexpression among normal oral mucosa, OL and OSCC. In addition, a significant positive correlation was found between TWIST and p-Akt expressions according to the Pearson's correlation test. Conclusions: The results obtained in the current study suggest that TWIST and p-Akt may participate of the multi-step process of oral carcinogenesis since its early stages.