Artículos de revistas
Synthesis of 1,2,3-triazolylpyranosides through click chemistry reaction
Fecha
2012Registro en:
TETRAHEDRON LETTERS, OXFORD, v. 53, n. 14, p. 1742-1747, APR 4, 2012
0040-4039
10.1016/j.tetlet.2012.01.102
Autor
Stefani, Helio Alexandre
Silva, Nathalia C. S.
Manarin, Flavia
Luedtke, Diogo S.
Zukerman-Schpector, Julio
Madureira, Lucas Sousa
Tiekink, Edward R. T.
Institución
Resumen
We have developed an efficient method for the synthesis of functionalized C-glycosyl 1,2,3-triazoles through a Cu(1)-promoted azide-alkyne 1,3-dipolar cycloaddition between a TMS-protected C-alkynyl-glycoside and organic azides. The reaction was accelerated by ultrasound irradiation and the addition of a base was not necessary to obtain the 1,2,3-triazole product. Moreover, further manipulation of the products led to chiral molecules with a C-glycoside linkage. (C) 2012 Elsevier Ltd. All rights reserved.