Artículos de revistas
DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Fecha
2012Registro en:
QUIMICA NOVA, SAO PAULO, v. 35, n. 3, supl. 18, Part 2, pp. 608-611, MAY, 2012
0100-4042
10.1590/S0100-40422012000300029
Autor
de Lima Gomes, Elionai Cassiana
Cunha Junior, Armando da Silva
Yoshida, Maria Irene
Jorge, Rodrigo
Institución
Resumen
DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. In this study, an analytical method was developed and validated for quantitation of the drug bevacizumab (Avastin (R)) by high performance liquid chromatography (HPLC). The HPLC column was a BioSuite 250 (R) HR SEC, 300 x 7.8 mm x 5 mu m (Waters, USA). The mobile phase consisted of phosphate buffered saline (PBS). The results revealed that the method was specific, precise. accurate, robust and linear (r(2) = 0.998) from 5 to 75 mu g mL(-1). Therefore, this method can be used in drug release studies or in quality control ampoules of the drug.