Artículos de revistas
Voxelwise evaluation of white matter volumes in first-episode psychosis
Fecha
2012Registro en:
PSYCHIATRY RESEARCH-NEUROIMAGING, CLARE, v. 202, n. 3, pp. 198-205, 11110, 2012
0925-4927
10.1016/j.pscychresns.2011.09.005
Autor
da Cunha Colombo, Renata Rodrigues
Schaufelberger, Maristela Spanghero
Santos, Luciana Cristina
Souza Duran, Fabio Luis de
Menezes, Paulo Rossi
Scazufca, Marcia
Busatto, Geraldo Filho
Zanetti, Marcus Vinicius
Institución
Resumen
The occurrence of white matter (WM) abnormalities in psychotic disorders has been suggested by several studies investigating brain pathology and diffusion tensor measures, but evidence assessing regional WM morphometry is still scarce and conflicting. In the present study, 122 individuals with first-episode psychosis (FEP) (62 fulfilling criteria for schizophrenia/schizophreniform disorder, 26 psychotic bipolar I disorder, and 20 psychotic major depressive disorder) underwent magnetic resonance imaging, as well as 94 epidemiologically recruited controls. Images were processed with the Statistical Parametric Mapping (SPM2) package, and voxel-based morphometry was used to compare groups (t-test) and subgroups (ANOVA). Initially, no regional WM abnormalities were observed when both groups (overall FEP group versus controls) and subgroups (i.e., schizophrenia/schizophreniform, psychotic bipolar I disorder, psychotic depression, and controls) were compared. However, when the voxelwise analyses were repeated excluding subjects with comorbid substance abuse or dependence, the resulting statistical maps revealed a focal volumetric reduction in right frontal WM, corresponding to the right middle frontal gyral WM/third subcomponent of the superior longitudinal fasciculus, in subjects with schizophrenia/schizophreniform disorder (n = 40) relative to controls (n = 89). Our results suggest that schizophrenia/schizophreniform disorder is associated with right frontal WM volume decrease at an early course of the illness. (c) 2012 Elsevier Ireland Ltd. All rights reserved.