Artículos de revistas
Molecular epidemiology of the SH (small hydrophobic) gene of human respiratory syncytial virus (HRSV), over 2 consecutive years
Fecha
2012Registro en:
VIRUS RESEARCH, AMSTERDAM, v. 163, n. 1, pp. 82-86, JAN, 2012
0168-1702
10.1016/j.virusres.2011.08.013
Autor
Lima, Hildener Nogueira
Botosso, Viviane Fongaro
Leal Oliveira, Danielle Bruna
Almeida Campos, Angelica Cristine de
Leal, Andrea Lima
Silva, Tereza Souza
Ramos Bosso, Patricia Alves
Pedroso Moraes, Claudia Trigo
Silva Filho, Claudionor Gomes da
Vieira, Sandra Elisabete
Gilio, Alfredo Elias
Stewien, Klaus Eberhard
Durigon, Edison Luiz
Institución
Resumen
Human respiratory syncytial virus (HRSV) strains were isolated from nasopharyngeal aspirates collected from 965 children between 2004 and 2005, yielding 424 positive samples. We sequenced the small hydrophobic protein (SH) gene of 117 strains and compared them with other viruses identified worldwide. Phylogenetic analysis showed a low genetic variability among the isolates but allowed us to classify the viruses into different genotypes for both groups, HRSVA and HRSVB. It is also shown that the novel BA-like genotype was well segregated from the others, indicating that the mutations are not limited to the G gene. (C) 2011 Elsevier B.V. All rights reserved.