Artículos de revistas
Hyaluronidase splice variants are associated with histology and outcome in adenocarcinoma and squamous cell carcinoma of the lung
Fecha
2012Registro en:
HUMAN PATHOLOGY, PHILADELPHIA, v. 43, n. 5, pp. 675-683, MAY, 2012
0046-8177
10.1016/j.humpath.2011.06.010
Autor
Sa, Vanessa Karen de
Olivieri, Eloisa
Parra, Edwin Roger
Ab'Saber, Alexandre Muxfeldt
Takagaki, Teresa
Soares, Fernando Augusto
Carraro, Dirce
Carvalho, Lina
Capelozzi, Vera Luiza
Institución
Resumen
Heterogeneity of hyaluronidase (HYAL) expression has been identified in tumors and shows promise as an indicator of disease progression. The expression profile of alternatively spliced forms of HYAL was evaluated in tumors and normal lung tissue from 69 resected tumors of patients with adenocarcinomas and squamous cell carcinomas. HYAL1-wild-type (wt) and variants 1 to 5, HYAL2-wt, and HYAL3-wt, and variants 1 to 3 were identified by polymerase chain reaction and direct sequencing. Different proportions of the 3 HYAL-wt and variants were expressed in tumor and normal lung tissues. HYAL1-wt was associated with a poorer prognosis and HYAL3-vl with a better prognosis. HYAL splice variants are associated with histology and outcome, suggesting that strategies aimed at modulating their levels may be effective for lung cancer treatment. (C) 2012 Elsevier Inc. All rights reserved.