Artículos de revistas
Histomorphometric analysis of the effects of creatine on rat myometrium
Fecha
2012Registro en:
GYNECOLOGICAL ENDOCRINOLOGY, NEW YORK, v. 28, n. 8, pp. 587-589, AUG, 2012
0951-3590
10.3109/09513590.2011.650748
Autor
Do Amaral, Vinicius Cestari
Simoes, Manuel De Jesus
Marcondes, Rodrigo Rodrigues
Matozinho Cubas, Jairo Jose
Baracat, Edmund Chada
Soares, Jose Maria, Jr.
Institución
Resumen
Objective: To analyze the myometrial thickness of rats subjected to creatine (Cr) ingestion. Study design: A total of 14 rats was equally divided into the control group (ConGr) receiving 1 ml potable water and the creatine group (CrGr) subjected to the ingestion of 1.6 g/kg Cr diluted in 1 ml potable water. At the end of 8 weeks, the animals were anesthetized (xylazine and ketamine) and sacrificed, the uteri and ovaries stained with hematoxylin and eosin, the thickness of both the myometrium and the epithelium measured and the follicles counted. Results: Analysis revealed a significant increase in thickness of the myometrium in the CrGr (272.26 +/- 66.71 mu m) contrasted with that from the ConGr (160.76 +/- 35.65 mu m), CrGr > ConGr (p < 0001). Conclusion: Our data suggest that Cr changed myometrial morphology in rats by enhancing myometrial thickness, but its action mechanism in the smooth muscle is still unclear.