Artículos de revistas
Implementing Human Papillomavirus Testing in a Public Health Hospital: Challenges and Opportunities
Fecha
2012Registro en:
ACTA CYTOLOGICA, BASEL, v. 56, n. 2, supl. 1, Part 3, pp. 160-165, DEC, 2012
0001-5547
10.1159/000335145
Autor
Beldi, Mariana Carmezim
Tacla, Maricy
Caiaffa-Filho, Helio
Ab'saber, Alexandre
Siqueira, Sheila
Baracat, Edmund Chada
Ferreira Alves, Venancio Avancini
Longatto-Filho, Adhemar
Institución
Resumen
Objectives: Robust evidence now supports human papillomavirus (HPV) testing as a more effective option to screening and as more sensitive than cytology in detecting high-grade cervical intraepithelial neoplasia. Our goal was to analyze the performance of the Hybrid Capture II (HC2) assay for high-risk HPV (hrHPV) in women undergoing gynecological examination at a public health hospital as part of the evaluation of HPV screening as an alternative or complement to cytology. Study Design: This analysis is a subset of a cross-sectional study carried out at a large public hospital serving a predominantly low-resource population. A total of 705 women were enrolled; the sensitivity and specificity of each test were estimated and compared. Results: The analysis identified 272 hrHPV-positive women (mean age 36.3 years) and 433 hrHPV-negative women (mean age 41.2 years). HPV testing showed a significantly increased sensitivity of the HC2 assay versus cytology (84.5 vs. 69.7%; p < 0.0001) but a lower specificity (49.90 vs. 88.78%; p < 0.0001). Conclusion: The combination of both methods seems to be useful in improving detection of cervical lesions. Copyright (C) 2012 S. Karger AG, Basel