Artículos de revistas
Estrogen receptor: Structural differences and potential implications on selectivity examined by the GRID/CPCA approach
Fecha
2008Registro en:
LETTERS IN DRUG DESIGN & DISCOVERY, v.5, n.3, p.182-192, 2008
1570-1808
10.2174/157018008784083947
Autor
MENEZES, I. R. A. de
LEITAO, A.
MONTANARI, C. A.
Institución
Resumen
Selective Estrogen Receptor Modulators ( SERMs) have been developed, but the selectivity towards the subtypes ( ER or ER is not well understood. Based on three-dimensional structural properties of ligand binding domains, a model that takes into account this aspect was developed via molecular interaction fields and consensus principal component analysis (GRID/CPCA).