Artículos de revistas
Oroidin Inhibits the Activity of the Multidrug Resistance Target Pdr5p from Yeast Plasma Membranes
Fecha
2011Registro en:
JOURNAL OF NATURAL PRODUCTS, v.74, n.2, p.279-282, 2011
0163-3864
10.1021/np1006247
Autor
SILVA, Fernanda R. da
TESSIS, Ana Claudia
FERREIRA, Patricia F.
RANGEL, Luciana P.
GARCIA-GOMES, Aline S.
PEREIRA, Fabio R.
BERLINCK, Roberto G. S.
MURICY, Guilherme
FERREIRA-PEREIRA, Antonio
Institución
Resumen
Oroidin was isolated from the marine sponge Agelas sventres and inhibited the activity and function of Pdr5p, an enzyme responsible for the multidrug resistance phenotype in Saccharomyces cerevisiae. This compound may help in the development of new drugs that reverse this dangerous phenotype of pathogenic yeast and fungi.