Artículos de revistas
Improving the enantioselective bioreduction of aromatic ketones mediated by Aspergillus terreus and Rhizopus oryzae: the role of glycerol as a co-solvent
Fecha
2009Registro en:
TETRAHEDRON-ASYMMETRY, v.20, n.13, p.1521-1525, 2009
0957-4166
10.1016/j.tetasy.2009.05.033
Autor
ANDRADE, Leandro H.
PIOVAN, Leandro
PASQUINI, Monica D.
Institución
Resumen
The improvement of the enzymatic performance of Aspergillus terreus and Rhizopus oryzae in enantioselective bioreductions by using glycerol as a co-solvent has been studied. In the most of the bioreductions, glycerol has demonstrated its potential for improved conversions (up to >99%) and enantioselectivities (up to >99%) when compared to reactions in aqueous or other aqueous-organic media (THF, diethyl ether, toluene, DMSO and acetonitrile). Moreover, high isolated yields of the desired chiral alcohols have been obtained on a preparative scale showing the great potential of this green solvent in biocatalysis. (C) 2009 Elsevier Ltd. All rights reserved.