Artículos de revistas
Synthesis of new fluorous modular chiral ligand derivatives from amino alcohols and application in enantioselective carbon-carbon bond-forming alkylation reactions
Fecha
2010Registro en:
TETRAHEDRON-ASYMMETRY, v.21, n.8, p.997-1003, 2010
0957-4166
10.1016/j.tetasy.2010.05.015
Autor
SEHNEM, Jasquer A.
MILANI, Priscila
NASCIMENTO, Vanessa
ANDRADE, Leandro H.
DORNELES, Luciano
BRAGA, Antonio L.
Institución
Resumen
N-Trifluoracyl beta-chalcogeno amides and N-perfluoracyl beta-thio amide ligands were prepared by a simple and efficient reaction sequence. These new ligands were evaluated in palladium-catalyzed alkylation of rac-(E)-1,3-diphenyl-2-propenyl acetate in the presence of dimethyl malonate and an enantioselectivity of up to 99% was obtained. After catalysis, the fluorous ligand can be easily recovered by liquid-liquid extraction and reused without loss in the activity. (C) 2010 Elsevier Ltd. All rights reserved.