Artículos de revistas
Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
Fecha
2009Registro en:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.44, n.10, p.4004-4009, 2009
0223-5234
10.1016/j.ejmech.2009.04.044
Autor
KUMMERLE, Arthur E.
RAIMUNDO, Juliana M.
LEAL, Carla M.
SILVA, Givanildo S. da
BALLIANO, Tatiane L.
PEREIRA, Mariano A.
SIMONE, Carlos A. de
SUDO, Roberto T.
ZAPATA-SUDO, Gisele
FRAGA, Carlos A. M.
BARREIRO, Eliezer J.
Institución
Resumen
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates. (C) 2009 Elsevier Masson SAS. All rights reserved.